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Laboratory
of Cell and Molecular Biology at
the Department of Signal Processing, Tampere University of Technology
Every cell is an individual, with unique
behavior. To learn what makes
them different in some ways and similar in other ways, we need to study
many
live cells from large populations. With this aim, new measurement
techniques
are rapidly emerging. Methods from Signal Processing are the
best candidates to interpret and integrate their results. A new laboratory of cell and molecular
biology has been built in the Dept. of Signal Processing at Tampere
University
of Technology, open to all research groups and students. By producing
biological data in-house, it will provide signal processors with direct
access
to new biological measurements for their projects and hands-on
experience on
techniques ranging from microscopy to qPCR.
This will
boost the development of computational methods such as image analysis
and
modeling and simulation tools to study complex biological phenomena.
In vivo detection of
RNA molecules, one molecule at a time, in live Escherichia
coli cells using the MS2-GFP system generously provided
by Professor Ido Golding. Top: one
example image; Bottom: a movie generated from time series measurements (from
Kandhavelu et al, BMC
Systems
Biology, 2011) Recent publications M Kandhavelu, H Mannerstrom, O Yli-Harja, and AS Ribeiro (2011) In vivo kinetics of transcription initiation of the lar promoter in Escherichia coli. Evidence for a sequential mechanism with two rate limiting steps. BMC Systems Biology, in press. Tampere, 2011 |
